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Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

10.2K

Management of older adults with myelodysplastic syndromes (MDS)

Marlise R Luskin1, Gregory A Abel1

  • 1Dana-Farber Cancer Institute, 450 Brookline Avenue, Dana 2056, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA.

Journal of Geriatric Oncology
|January 2, 2018
PubMed

Insights

Myelodysplastic syndromes (MDS) are bone marrow failure disorders common in older adults, impacting quality of life and survival. Treatment must consider patient frailty and comorbidities alongside disease risk.

Area of Science:

  • Hematology
  • Oncology
  • Geriatrics

Background:

  • Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders.
  • MDS leads to bone marrow failure and can progress to acute myeloid leukemia.
  • The median age of MDS diagnosis is over 70, with frequent comorbidities and frailty.

Purpose of the Study:

  • To review the characteristics of MDS in an elderly population.
  • To discuss the impact of comorbidities and frailty on prognosis and treatment.
  • To emphasize tailored therapeutic approaches for older MDS patients.

Main Methods:

  • Literature review of myelodysplastic syndromes in elderly patients.
  • Analysis of prognostic factors including age, comorbidities, and frailty.
  • Evaluation of current treatment strategies for MDS.

Main Results:

  • MDS predominantly affects individuals over 70 years old.
  • Comorbidities and frailty significantly influence MDS prognosis and treatment decisions.
  • Supportive care is primary; disease-modifying therapies are reserved for fit patients.

Conclusions:

  • Optimal management of MDS in older adults requires a comprehensive assessment of disease risk, comorbidities, and patient frailty.
  • Treatment strategies should be individualized to balance therapeutic benefits with potential toxicities.
  • Geriatric principles are essential for managing MDS patients effectively.
Keywords:
Allogeneic hematopoietic stem cell transplantComorbidityFrailtyMyelodysplastic syndromesOlder adults

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