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Prolonged Dexmedetomidine Infusion and Drug Withdrawal In Critically Ill Children

Astrid S Haenecour1, Winnie Seto1, Charline M Urbain1

  • 1Department of Critical Care Medicine (ASH, WS, PCL, CRB), The Hospital for Sick Children, Toronto, Canada; Department of Pharmacy (WS), The Hospital for Sick Children, Toronto, Canada; Department of Diagnostic Imaging and Neuroscience & Mental Health Program (CMU), The Hospital for Sick Children Research Institute, Toronto, Canada; Department of Clinical research services (DS), The Hospital for Sick Children, Toronto, Canada; and University of Toronto (DRB, PCL, WS), Toronto, Ontario, Canada.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
|January 2, 2018
PubMed
Summary

Prolonged dexmedetomidine infusions in critically ill children can lead to withdrawal symptoms in 35% of cases. Higher cumulative doses and longer opioid use increase withdrawal risk, suggesting a need for weaning protocols.

Keywords:
dexmedetomidineinfusionintensive care unitintravenouspediatricsubstance withdrawal syndrome

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