Related Experiment Video
Updated: Feb 16, 2026
07:17
An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Published on: September 24, 2020
12.6K
Neoadjuvant therapy for resectable pancreatic cancer
Sheikh Hasibur Rahman1, Robin Urquhart1, Michele Molinari2
1Department of Surgery, Dalhousie University, Halifax B3H 2Y9, Nova Scotia, Canada.
World Journal of Gastrointestinal Oncology
|January 2, 2018
Summary
Neoadjuvant therapies improve surgical outcomes for advanced pancreatic cancer (PC). However, evidence is needed to confirm benefits for resectable PC, balancing risks against potential survival gains.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Neoadjuvant therapies are crucial for borderline resectable and locally advanced pancreatic cancers (PCs).
- Preoperative treatments enhance resectability and survival rates in these advanced PC cases.
- Current survival rates for resectable PC necessitate novel treatment strategies.
Purpose of the Study:
- To review recent evidence on neoadjuvant therapies for pancreatic cancer.
- To evaluate the benefits and risks of neoadjuvant approaches in PC management.
- To inform clinical decision-making regarding neoadjuvant treatment for PC.
Main Methods:
- Literature review of recent studies on neoadjuvant therapies for PC.
- Analysis of evidence regarding efficacy and safety of preoperative treatments.
- Synthesis of current data on survival and quality of life outcomes.
Main Results:
- Neoadjuvant therapy improves outcomes for advanced pancreatic cancer (PC).
- Evidence supporting neoadjuvant therapy for resectable PC is still developing.
- Potential risks include tumor progression during the waiting period for surgery.
Conclusions:
- Neoadjuvant therapies offer significant benefits for specific PC patient groups.
- Further research is essential to establish the role of neoadjuvant treatment in resectable PC.
- Balancing treatment benefits against risks is critical for optimizing PC patient care.
Related Concept Videos
02:49Cancer Therapies
10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
02:57Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
00:59Gene Therapy
27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
01:26Group Therapy
472
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
472
01:22Behavior Therapy
758
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
758
01:28Drug Therapy
312
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
312