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Staphylococcus epidermidis isolates from nares and prosthetic joint infections are mupirocin susceptible

Lavin Salih1, Staffan Tevell1,2, Emeli Månsson1,3

  • 1School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Journal of Bone and Joint Infection
|January 2, 2018
PubMed

Insights

Staphylococcus epidermidis causing prosthetic joint infections exhibit high multi-drug resistance, unlike nasal isolates. Most isolates remained susceptible to mupirocin, suggesting PJIs do not originate from nasal carriage.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Orthopedics

Background:

  • Staphylococcus epidermidis is a common cause of prosthetic joint infections (PJIs).
  • Nasal carriage of Staphylococcus species is a potential source for infections.
  • Mupirocin is used to eradicate nasal Staphylococcus aureus carriers.

Purpose of the Study:

  • To determine the antibiotic susceptibility of Staphylococcus epidermidis from PJIs and nasal isolates.
  • To investigate mupirocin susceptibility in these isolates.
  • To assess the potential origin of S. epidermidis in PJIs.

Main Methods:

  • Antibiotic susceptibility testing using disc diffusion and gradient tests.
  • Analysis of isolates from prosthetic joint infections (n=183) and nasal carriers (n=75).
  • Evaluation of susceptibility to mupirocin and other antimicrobial agents.

Main Results:

  • High multi-drug resistance (84.2%) observed in PJI isolates compared to nasal isolates (2.7%).
  • Nearly all isolates (PJI and nasal) were susceptible to mupirocin.
  • Significant difference in multi-drug resistance patterns suggests distinct origins.

Conclusions:

  • Staphylococcus epidermidis causing PJIs are frequently multi-drug resistant.
  • Nasal isolates of S. epidermidis show significantly lower resistance.
  • PJIs caused by S. epidermidis likely do not originate from nasal carriage.
Keywords:
Antibiotic susceptibility testingMupirocinProsthetic joint infectionsStaphylococcus epidermidis

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