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Updated: Feb 16, 2026

Lower Limb Biomechanical Analysis of Healthy Participants
Published on: April 15, 2020
Do you want to participate in a clinical study as a healthy control? - Risk or benefit?
Hanna Giessen1, Christian A Nebiker2, Matthias Bruehlmeier3
1Department of Internal Medicine, Kantonsspital Aarau, Aarau 5000, Switzerland.
Abstract:
A healthy woman volunteered to participate as "healthy control" in a study. An increased level of procalcitonin (PCT) was detected and remained elevated on follow-up measurements. As calcitonin levels were elevated as well, thyroid ultrasound was performed which revealed nodes in both thyroid lobes, one of them showing metabolic activity in positron emission tomography-computed tomography scan. To exclude a malignant thyroid cancer despite the negative findings in a fine needle aspiration the patient underwent thyroidectomy and a medullary thyroid carcinoma (MTC) was detected in the right lobe. MTC is a rare endocrine tumor with a poor prognosis once having spread, therefore early detection remains a priority for the outcome. Screening parameter is serum calcitonin, in absence of infection the pro-hormone PCT can be used as a screening parameter as well with high sensitivity.
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