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Related Experiment Videos

Liver 'organ on a chip'.

Colin H Beckwitt1, Amanda M Clark2, Sarah Wheeler2

  • 1Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA; The McGowan Institute of Regenerative Medicine University of Pittsburgh, Pittsburgh, PA 15213, USA; Research and Development Service, VA Pittsburgh Health System, Pittsburgh, PA 15240, USA.

Experimental Cell Research
|January 2, 2018
PubMed
Summary

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This summary is machine-generated.

Researchers are developing advanced liver tissue models for studying drug toxicity, diseases, and regeneration. These engineered organoids and microphysiological systems offer new ways to understand liver function and pathology outside the body.

Area of Science:

  • Hepatology and Regenerative Medicine
  • Drug Metabolism and Toxicology
  • Biomedical Engineering

Background:

  • The liver is vital for homeostasis and pathology, acting as the primary site for drug metabolism and a target for toxicity.
  • It is susceptible to numerous diseases, yet possesses a unique capacity for regeneration.
  • Understanding liver physiology, disease, and responses to external compounds is crucial.

Purpose of the Study:

  • To review the development of in vitro liver tissue systems.
  • To highlight the utility of engineered organoids and microphysiological systems for liver research.
  • To explore their application in studying liver function, disease, and drug responses.

Main Methods:

  • Review of biologically engineered liver organoids.
Keywords:
3D culture systemsMicrophysiologic systemsOrganoids

Related Experiment Videos

  • Discussion of microphysiological systems for liver research.
  • Analysis of current technologies for in vitro liver modeling.

    • Main Results:

    • Engineered liver tissue systems, including organoids and microphysiological systems, are advancing.
    • These models provide platforms for studying liver-specific functions and pathologies.
    • They enable research on drug metabolism, toxicity, and regenerative processes.

    Conclusions:

    • Biologically engineered liver tissue systems are essential tools for modern research.
    • These advanced models facilitate a deeper understanding of liver physiology and disease.
    • They offer promising avenues for drug development and personalized medicine.