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Updated: Feb 16, 2026

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Published on: May 28, 2007
Case series: Slowing alpha rhythm in late-stage ALS patients
Matthias R Hohmann1, Tatiana Fomina1, Vinay Jayaram1
1Max Planck Institute for Intelligent Systems, Department for Empirical Inference, Max-Planck-Ring 4, 72076 Tübingen, Germany; International Max Planck Research School for Cognitive and Systems Neuroscience, Österbergstr. 3, 72074 Tübingen, Germany.
Abstract:
The alpha peak frequency (APF) of the human electroencephalogram (EEG) is a reliable neurophysiological marker for cognitive abilities. In these case series, we document a shift of the APF towards the lower end of the EEG spectrum in two completely locked-in ALS patients. In not completely locked-in ALS patients, the alpha rhythm lies within the common frequency range. We discuss potential implications of this shift for the largely unknown cognitive state of completely locked-in ALS patients.
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