[Pachydermoperiostosis--development of bone changes 25 years after disease onset]

Pachydermoperiostosis-hyperostosis generalisata cum pachydermia is considered a sex-linked hereditary pathological disposition of the mesenchyme with a favourable course of the dominant form; it is, however, progressively malignant in the recessive type of heredity. As a rule men affected. The author describes the case of a patient where the disease was diagnosed 25 years previously.