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[Familial colon cancer].

J Karner-Hanusch1, W Feil, R Schiessel

  • 1I. Chirurgische Universitätsklinik, Wien.

Wiener Klinische Wochenschrift
|February 17, 1989
PubMed
Summary

Familial colonic cancer, an inherited trait, frequently presents in the right colon and is often diagnosed around age 44. Early diagnosis through family history and surveillance is crucial for managing this condition.

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Area of Science:

  • Oncology
  • Genetics
  • Gastroenterology

Background:

  • Autosomal dominant inherited colonic cancer predisposes families to colorectal carcinomas.
  • Understanding familial cancer characteristics is vital for early detection and management.

Observation:

  • 54 family members across 5 families were analyzed for familial colonic cancer traits.
  • 45% of members had colorectal cancer, averaging 4.5 affected individuals per family.
  • The mean age of diagnosis was 43.9 years, with 50% of tumors in the right colon.

Findings:

  • 11 of 14 carcinomas were Dukes C, predominantly poorly differentiated or mucin-producing adenocarcinomas.
  • Synchronous (22%) and metachronous (13%) cancers were common; 8.7% had other cancer locations.
  • Screening asymptomatic relatives revealed neoplasms in 50% of subjects.

Implications:

  • Meticulous surveillance and accurate family history are essential for diagnosing and managing inherited colorectal cancer.
  • Early identification of familial colonic cancer enables timely intervention and improved patient outcomes.
  • This study highlights the aggressive nature and specific characteristics of hereditary colorectal cancer.

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