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Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
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Renal Corpuscle01:20

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
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Renal Clearance01:23

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The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

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Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
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Direct Drug Delivery to Kidney via the Renal Artery
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Advances in Renal Cell Imaging.

Georgina Gyarmati1, Hiroyuki Kadoya2, Ju-Young Moon3

  • 1Department of Physiology and Neuroscience, Department of Medicine, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Seminars in Nephrology
|January 3, 2018
PubMed
Summary
This summary is machine-generated.

Renal cell imaging advances diagnostics and treatments for kidney diseases. New optical imaging techniques, like intravital multiphoton fluorescence microscopy, offer deeper insights into kidney pathologies.

Keywords:
Genetic cell fate trackingcalcium signalingcell metabolismischemia-reperfusion injurymultiplex imaging fibrosis

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Area of Science:

  • Nephrology
  • Biomedical Imaging
  • Cell Biology

Background:

  • Cell imaging is crucial for studying kidney cells in research, drug development, and clinical settings.
  • Quantitative analysis of kidney cells aids in understanding disease mechanisms and identifying therapeutic targets.
  • Renal cell imaging holds promise for personalized diagnostics and treatments in kidney disease.

Purpose of the Study:

  • To review recent advancements in renal cell optical imaging.
  • To highlight how these techniques improve understanding of kidney pathologies.
  • To showcase the potential of imaging for diagnosing and treating kidney diseases.

Main Methods:

  • Review of current literature on renal cell imaging technologies.
  • Focus on intravital multiphoton fluorescence microscopy.
  • Examples of new knowledge gained from these imaging approaches.

Main Results:

  • Various cell imaging technologies are routinely used for kidney cell investigation.
  • Quantitative visualization and analysis of kidney cells reveal disease mechanisms.
  • Advanced optical imaging provides novel insights into renal pathologies.

Conclusions:

  • Renal cell imaging significantly enhances the precision of diagnostic and treatment paradigms.
  • Intravital multiphoton fluorescence microscopy is a key technique for understanding renal pathologies.
  • These imaging approaches are vital for advancing personalized medicine in nephrology.