Related Experiment Video
Updated: Feb 16, 2026

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
Published on: July 19, 2019
The Structure of the FACT-Cog v3 in Cancer Patients, Students, and Older Adults
Daniel S J Costa1, Vanessa Loh2, Damian P Birney2
1Pain Management Research Institute, Royal North Shore Hospital, St Leonards, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Context:
The Functional Assessment of Cancer Therapy-Cognitive (FACT-Cog) version 3 questionnaire is designed to assess perceived cognitive function and impact on quality of life in cancer patients.
Objectives:
We examined the factor structure of the FACT-Cog version 3 in samples of cancer patients, older adults, and students.
Methods:
Data from three populations were sourced. Cancer patient data (N = 158) came from two studies, one evaluating a web-based cognitive training program, and the other evaluating symptoms in patients receiving chemotherapy. The older adult sample (N = 477) was commercial brain training users in the general population. The student sample (N = 154) came from a study examining the relation between cognitive test performance and perceived cognitive function.
Results:
The patient sample conformed to the traditional four-factor structure (impairments, abilities, noticeability, and quality of life), with some support for separating the broad impairment/ability factors into specific cognitive domains. The older adult sample was best described using both impairments/abilities and specific cognitive domains. The student sample suggested two impairment/ability factors but separation of concentration/acuity and memory/verbal impairment items.
Conclusion:
The FACT-Cog can be used in populations other than cancer patients, with modifications to the scoring system. Even when used with cancer patients, it is worth considering scoring specific cognitive domains separately.
Related Concept Videos
Student t Distribution
The Student t distribution was developed by William S. Goset (1876–1937) of the...
Microsoft Excel: Student's t-Test
To conduct a t-test in Excel, use the T.TEST function or the "Data...
Comparing Experimental Results: Student's t-Test
Adult Stem Cells
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Structures of Solids

