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Updated: Feb 16, 2026

Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase
Published on: September 22, 2012
Serial quantitative neuroimaging of iron in the intracerebral hemorrhage pig model
Muhammad E Haque1, Refaat E Gabr2, Xiurong Zhao1
11 Institute for Stroke and Cerebrovascular Disease, McGovern 12339 Medical School at UTHealth , University of Texas Health Science Center at Houston, Houston, TX, USA.
Abstract:
Iron released after intracerebral hemorrhage (ICH) is damaging to the brain. Measurement of the content and distribution of iron in the hematoma could predict brain damage. In this study, 16 Yorkshire piglets were subjected to autologous blood injection ICH model and studied longitudinally using quantitative susceptibility mapping and R2* relaxivity MRI on day 1 and 7 post-ICH. Phantom calibration of susceptibility demonstrated (1) iron distribution heterogeneity within the hematoma and (2) natural absorption of iron from 154 ± 78 µg/mL (day 1) to 127 ± 33 µg/mL (day 7). R2* in the hematoma decreased at day 7. This method could be adopted for ICH in humans.
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