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Updated: Feb 16, 2026
18:48
Murine Renal Transplantation Procedure
Published on: July 10, 2009
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Long-Term Outcomes of Renal Transplant in Recipients With Lower Urinary Tract Dysfunction
Rebekah S Wilson1, Aisling E Courtney, Dicken S C Ko
1From the Regional Nephrology Unit, Belfast City Hospital, Belfast, Northern Ireland, UK.
Summary
Lower urinary tract dysfunction (LUTD) does not negatively impact kidney transplant outcomes. Patients with LUTD, even with prior interventions, showed similar graft and patient survival rates compared to controls.
Area of Science:
- Nephrology
- Urology
- Transplantation
Background:
- Lower urinary tract dysfunction (LUTD) can progress to end-stage renal disease (ESRD), potentially complicating kidney transplantation.
- Concerns exist regarding the impact of LUTD on the success of renal allografts, despite some smaller studies suggesting no adverse effect.
- Northern Ireland's high incidence of neural tube defects provides extensive local experience with LUTD management.
Purpose of the Study:
- To analyze and compare the outcomes of renal transplant recipients with and without lower urinary tract dysfunction.
- To determine if pre-existing lower urinary tract dysfunction affects graft and patient survival post-kidney transplantation.
Main Methods:
- A retrospective analysis of 150 kidney transplant recipients treated between 2001 and 2010.
- Patients were categorized into three groups: ESRD due to LUTD with prior intervention, LUTD without intervention, and a control group with ESRD due to polycystic kidney disease.
- Primary outcome was death-censored graft survival; secondary outcomes included patient survival and graft function.
Main Results:
- Five-year death-censored graft survival rates were high across all groups: 93.75% (LUTD with intervention), 90.6% (LUTD without intervention), and 92.9% (control).
- No significant differences in graft failure were observed among the three groups.
- Five-year patient survival rates were also comparable, with 100% in the first two groups and 94.3% in the control group.
Conclusions:
- Renal transplant recipients with a history of lower urinary tract dysfunction demonstrate graft and patient survival rates similar to those without this comorbidity.
- Appropriate management of lower urinary tract dysfunction does not represent a contraindication for successful kidney transplantation.
- This study supports the acceptance of patients with LUTD for renal transplantation, provided their condition is adequately managed.
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