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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
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Double trouble: psoriasis and cardiometabolic disorders
Nasrin Goolam Mahyoodeen1, Nigel J Crowther2, Mohammed Tikly1
1Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Cardiovascular Journal of Africa
|January 3, 2018
Summary
Psoriasis (PsO) is linked to increased cardiometabolic disease (CMD) risk due to chronic inflammation and shared risk factors. Managing inflammation and CMD is crucial for patients with psoriasis.
Area of Science:
- Dermatology
- Cardiology
- Metabolic Diseases
Background:
- Psoriasis (PsO) is a chronic inflammatory skin condition.
- PsO is associated with numerous co-morbidities, particularly cardiometabolic diseases (CMD).
Purpose of the Study:
- To review the epidemiology and pathogenetic mechanisms linking PsO and CMD.
- To discuss factors contributing to the increased risk of cardiovascular morbidity and mortality in PsO patients.
Main Methods:
- Descriptive review of registry-based studies.
- Analysis of epidemiological data and pathogenetic mechanisms.
Main Results:
- PsO is associated with an elevated risk of cardiovascular morbidity and mortality.
- Key linking factors include chronic inflammation, obesity, traditional cardiovascular risk factors, and systemic therapies.
- Inflammation from PsO and obesity creates a pro-atherogenic environment.
Conclusions:
- Systemic therapies reducing inflammation may improve CMD in PsO patients.
- Screening for and treating CMD, alongside lifestyle modifications, are vital interventions.
- Further research is needed on the impact of systemic therapy on CMD progression.
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