Related Experiment Video
Updated: Feb 16, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
Published on: August 15, 2020
Impact of epigenetics in aging and age related neurodegenerative diseases
Omkaram Gangisetty1, Miguel A Cabrera2, Sengottuvelan Murugan2
1Endocrine Research Facility, Dept. of Animal Sciences, Rutgers University, 67 Poultry Farm Lane, New Brunswick, NJ-08901, og53@sebs.rutgers.edu.
Abstract:
Epigenetics involves multiple processes such as DNA methylation, histone code modifications, and noncoding RNAs to regulate gene expression. In recent years the implications of epigenetic mechanisms have emerged in the field of neuroscience especially in brain development, memory, learning, and various cognition processes. Epigenetics also plays a pivotal role during the aging process of the brain which has led to various age-related neurodegenerative diseases. This manuscript portrays the findings of various epigenetic mechanisms that play a critical role and their implications in aging as well as age-related neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Related Concept Videos
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Pharmacodynamics in Geriatric Patients: Effects of Age
Epigenetic Regulation
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

