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Bortezomib for Refractory Immune-Mediated Thrombocytopenia Purpura

Joan D Beckman¹, Marian A Rollins-Raval², Jay S Raval²

¹Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC.

American Journal of Therapeutics

|January 3, 2018

Abstract:

The treatment of refractory immune-mediated thrombocytopenia purpura (ITP) can be challenging. This case report describes treatment of refractory ITP with bortezomib, a proteasome inhibitor. This strategy has been successful in relapsing thrombotic thrombocytopenic purpura but is a novel therapeutic approach for ITP. Further research use of proteasome inhibition in refractory ITP may be warranted.

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