Flow resistance in the feline choledocho-duodenal sphincter as studied by constant-pressure and constant-perfusion...

During interdigestive periods, there is a resistance to flow in the biliary tract exerted by the sphincter of Oddi, resulting in a pressure gradient between the common bile duct and the duodenum. In this experimental study, this flow resistance was studied with both a constant-flow and a constant-perfusion technique in fasted, anaesthetized cats. The flow resistance exerted by the sphincter is higher when it is perfused by a constant flow compared to when the common bile duct pressure is kept constant and the flow varies in response to its muscular activity. It was demonstrated with each method that the flow resistance in the choledocho-duodenal junction is reduced in response to distension of the biliary tree and gallbladder and also by distension of the duodenum. Cholecystokinin was shown to reduce the flow resistance in the choledocho-duodenal junction as estimated with either method.