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Updated: Feb 16, 2026
10:35
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
18.8K
Image-Guided Robotic Radiosurgery for Trigeminal Neuralgia
Pantaleo Romanelli1, Alfredo Conti2, Livia Bianchi1
1Centro Diagnostico Italiano, Milan, Italy.
Neurosurgery
|January 3, 2018
Summary
Frameless radiosurgery effectively treats trigeminal neuralgia (TN), offering sustained pain relief for most patients. Re-irradiation may increase sensory complications, but overall, this treatment is safe and effective for TN.
Area of Science:
- Neurosurgery
- Radiation Oncology
Background:
- Trigeminal neuralgia (TN) presents challenges for medically resistant cases.
- Frameless, non-isocentric stereotactic radiosurgery offers novel approaches for TN treatment.
Purpose of the Study:
- To evaluate the outcomes of image-guided robotic radiosurgery for TN.
- To report the largest single-center experience with this treatment modality for TN.
Main Methods:
- 138 patients with TN underwent CyberKnife® radiosurgery with a minimum 36-month follow-up.
- Prospective analysis included pain relief, medication use, sensory disturbances, and pain recurrence rates.
Main Results:
- Actuarial pain control rates (BNI class I-IIIa) at 36 months were 76%.
- 24% of patients required a second treatment, and 18.1% developed sensory disturbances.
- Shorter nerve length, smaller nerve volume, and lower prescription dose were associated with treatment failure.
Conclusions:
- Targeting a 6-mm trigeminal nerve segment with 60 Gy is safe and effective for TN.
- Acceptable pain control is achievable with manageable sensory complication risks, particularly after re-irradiation.
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