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[The role of proprotein convertases in cancer diseases with particular focus on PACE4]

Izabela Małuch1, Marta Makowska1, Marta Tomczykowska1

  • 1Laboratory of Biopolymers Structural Research, Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, 63 Wita Stwosza St., 80-308 Gdansk, Poland.

Postepy Biochemii
|January 3, 2018
PubMed

Insights

Proprotein convertases (PCs) are enzymes involved in cancer progression. Understanding their role is key to developing targeted cancer therapies using PC inhibitors.

Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Cancer remains a leading cause of mortality worldwide.
  • Understanding tumorigenesis and tumor cell invasiveness is vital for developing targeted therapies.
  • Proteolytic enzymes are implicated in cancer development and progression, serving as potential tumor markers.

Purpose of the Study:

  • To elucidate the role of proprotein convertases (PCs) in cancer pathogenesis and progression.
  • To explore the potential of PCs as therapeutic targets in cancer treatment.

Main Methods:

  • Review of existing literature on proprotein convertases and cancer.
  • Analysis of the involvement of PCs in molecular mechanisms of cancer development.
  • Identification of potential therapeutic strategies targeting PCs.

Main Results:

  • Proprotein convertases (PCs) play a significant role in the pathogenesis and progression of various cancers.
  • PCs are implicated in key cellular processes driving tumor growth and metastasis.
  • The study highlights the potential of targeting PCs for novel cancer treatments.

Conclusions:

  • Proprotein convertases are critical players in cancer development and invasiveness.
  • Inhibitors of proprotein convertases represent a promising avenue for future molecular targeted cancer therapies.
Keywords:
PACE4furininhibitorproprotein convertases

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