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Updated: Feb 16, 2026
07:14
Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
Published on: May 30, 2025
969
Integration of Murine and Human Studies for Mapping Periodontitis Susceptibility
A Nashef1, R Qabaja1, Y Salaymeh2
11 Department of Prosthodontics, Hadassah Faculty of Dental Medicine, Hebrew University, Jerusalem, Israel.
Journal of Dental Research
|January 3, 2018
Summary
Genetic mapping in mice identified two significant loci associated with periodontitis susceptibility. Further analysis in human populations is needed to confirm these findings and identify specific genes contributing to this common inflammatory disease.
Area of Science:
- Genetics
- Periodontology
- Inflammatory Diseases
Background:
- Periodontitis is a common inflammatory disease with a significant genetic basis.
- Genome-wide association studies (GWASs) for periodontitis have been limited by small sample sizes and trait heterogeneity.
- Discovering common susceptibility factors requires novel approaches combining animal models and human data.
Purpose of the Study:
- To identify novel genetic loci associated with periodontitis susceptibility using a mouse model.
- To investigate the human orthologous regions of identified mouse loci for association with periodontitis in human cohorts.
- To refine quantitative trait loci (QTL) for alveolar bone loss in the Collaborative Cross (CC) mouse population.
Main Methods:
- Quantitative trait loci (QTL) mapping was performed in 25 lines of the Collaborative Cross (CC) mouse population to assess alveolar bone loss.
- Micro-computed tomography (µCT) was used to analyze bone loss in response to experimental periodontal infection in mice.
- Association analyses were conducted on human case-control samples (aggressive and chronic periodontitis) using imputed genotype data from orthologous chromosomal regions.
Main Results:
- QTL mapping in mice revealed two significant loci, Perio3 on chromosome 1 and Perio4 on chromosome 14, associated with alveolar bone loss.
- The Perio3 locus overlaps with a previously reported QTL and contains the murine gene Ccdc121, whose human orthologue showed nominal association with chronic periodontitis.
- Further refinement of QTL in mice suggested seven candidate genes, but no significant association was found with their human orthologues in the studied human cohorts.
Conclusions:
- The Collaborative Cross mouse population enabled the mapping of confined QTL related to alveolar bone loss, a key feature of periodontitis.
- Identifying true genetic risk factors for periodontitis in humans may require larger sample sizes and integration of additional data, such as gene expression in gingival tissues.
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