Related Experiment Video

Updated: Feb 16, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Using Therapeutic Circles to Visualize Guideline-Based Therapeutic Recommendations for Patients with Multiple Chronic

Brigitte Séroussi1, Alexandre Galopin2, Mouhssin Gaouar1

  • 1Sorbonne Universités, UPMC Université Paris 06, UMR_S 1142, LIMICS, Paris, France; INSERM, U1142, LIMICS, Paris, France; Université Paris 13, Sorbonne Paris Cité, LIMICS (UMR_S 1142), Bobigny, France.

Studies in Health Technology and Informatics
|January 4, 2018
PubMed

Insights

We developed GO-DSS, a clinical decision support system (CDSS), to reconcile multiple clinical practice guidelines (CPGs) for patients with co-occurring conditions. The system demonstrated high usability in managing complex medication recommendations.

Area of Science:

  • Medical Informatics
  • Artificial Intelligence in Healthcare
  • Ontology Engineering

Background:

  • Clinical decision support systems (CDSSs) can improve adherence to clinical practice guidelines (CPGs).
  • Existing CPGs often focus on single diseases, lacking support for managing interactions in patients with multiple conditions.
  • Managing polypharmacy and drug interactions is a significant challenge in complex patient care.

Purpose of the Study:

  • To develop and evaluate GO-DSS, a novel CDSS for reconciling CPGs in patients with comorbid conditions.
  • To address the limitations of single-disease CPGs by providing integrated recommendations.
  • To assess the usability of GO-DSS and its innovative "therapeutic circles" graphical interface.

Main Methods:

  • Developed GO-DSS, a CDSS utilizing ontological reasoning for CPG reconciliation.
  • Applied GO-DSS to the concurrent management of hypertension, type 2 diabetes, and dyslipidemia.
  • Designed an innovative graphical interface displaying medication recommendations as "therapeutic circles".
  • Conducted a qualitative evaluation using the think-aloud method with 12 users on simulated patient cases.

Main Results:

  • GO-DSS successfully implemented ontological reasoning for CPG reconciliation.
  • The "therapeutic circles" interface visually represented complex medication recommendations.
  • The system achieved a high mean usability rating of 90.7% based on the System Usability Scale.
  • Users found the system highly usable for managing multiple conditions.

Conclusions:

  • GO-DSS offers a promising approach to reconcile conflicting CPG recommendations for patients with multiple chronic conditions.
  • The ontological reasoning and "therapeutic circles" interface enhance usability and support for complex medication management.
  • The high usability ratings indicate the potential of GO-DSS in clinical practice for improving patient care and safety.

Keywords:
ClinicalComputer GraphicsComputer-AssistedDecision MakingDecision Support Systems

More Related Videos

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

10.5K
Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

1.1K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.1K
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
7.0K
Therapeutic Communication01:30

Therapeutic Communication

Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
8.8K
Cholinergic Antagonists: Therapeutic Uses01:26

Cholinergic Antagonists: Therapeutic Uses

Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:    
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
1.5K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.3K