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Stromal Expression of MARCKS Protein in Ovarian Carcinomas Has Unfavorable Prognostic Value

Raoudha Doghri1, Maroua Manai2,3,4, Pascal Finetti5

  • 1Département d'Anatomie Pathologique, Institut Salah Azaiez, Bab Saadoun, Tunis 1006, Tunisia. raoudha.doghri@gmail.com.

International Journal of Molecular Sciences
|January 4, 2018
PubMed

Insights

Myristoylated alanine-rich C-kinase substrate (MARCKS) is overexpressed in ovarian tumor stroma, correlating with poor overall survival. Targeting stromal MARCKS may offer a new therapeutic strategy for epithelial ovarian cancer (EOC).

Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Cancer Biology

Background:

  • Epithelial ovarian cancer (EOC) is a leading cause of gynecologic cancer mortality, necessitating novel therapeutic targets.
  • Myristoylated alanine-rich C-kinase substrate (MARCKS) is implicated in cancer progression, with inhibitors under development.

Purpose of the Study:

  • To investigate MARCKS expression in normal ovarian and EOC tissues.
  • To determine the correlation between MARCKS expression and clinicopathological features, including overall survival (OS).

Main Methods:

  • Retrospective immunohistochemistry (IHC) analysis of MARCKS in 118 EOC and 40 normal ovarian tissue samples.
  • Comparison of MARCKS expression between normal and tumor tissues.
  • Correlation analysis with clinicopathological features and OS.

Main Results:

  • Epithelial MARCKS staining was less frequent in EOC (50%) than normal samples (75%).
  • Stromal MARCKS expression was significantly higher in EOC (77%) compared to normal samples (22%).
  • Stromal MARCKS overexpression correlated with shorter OS in both univariate and multivariate analyses.

Conclusions:

  • Stromal MARCKS overexpression is associated with poor prognosis in EOC.
  • MARCKS may play a role in cancer-associated fibroblast activation within the tumor stroma.
  • Targeting stromal MARCKS represents a potential therapeutic avenue for EOC.
Keywords:
MARCKSepithelial ovarian cancerimmunohistochemistryprognosisstromasurvival

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