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Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights
María Vallet-Regí1,2, Montserrat Colilla3,4, Isabel Izquierdo-Barba5,6
1Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain. vallet@ucm.es.
None:
This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to target the diseased tissue and release the cargo on demand upon exposition to internal or external stimuli. The degradation rate of these nanocarriers in diverse physiological fluids is overviewed obeying their significance for their potential translation towards clinical applications. To conclude, the balance between the benefits and downsides of this revolutionary nanotechnological tool is also discussed.
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