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U-Shaped and Surface Functionalized Polymer Optical Fiber Probe for Glucose Detection.

Mikel Azkune1, Leire Ruiz-Rubio2, Gotzon Aldabaldetreku3

  • 1Department of Communications Engineering, University of the Basque Country (UPV/EHU), Engineering School of Bilbao, Plaza Ingeniero Torres Quevedo, 1, E-48013 Bilbao, Spain. mikel.azkune@ehu.eus.

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Summary

This study presents a novel optical fiber probe for detecting glucose in physiological samples. The U-shaped, functionalized fiber probe demonstrates high selectivity and sensitivity for cost-effective glucose monitoring.

Keywords:
absorption evanescent wave sensingbio-chemical sensingpolymer optical fiberssurface functionalization

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Area of Science:

  • Biomedical Engineering
  • Optical Sensing
  • Analytical Chemistry

Background:

  • Accurate glucose detection is crucial for diabetes management.
  • Existing glucose monitoring methods have limitations in selectivity, sensitivity, or cost.
  • Optical fiber sensing offers potential for non-invasive and continuous glucose monitoring.

Purpose of the Study:

  • To develop and demonstrate an optical fiber evanescent wave absorption probe for glucose detection.
  • To enhance probe selectivity and sensitivity using specific material functionalization and geometric design.
  • To evaluate the probe's performance in various physiological media.

Main Methods:

  • Fabrication of an only-core poly(methyl methacrylate) (PMMA) polymer optical fiber.
  • Functionalization of the fiber surface with phenilboronic groups for glucose binding.
  • U-shaped fiber geometry to enhance light-matter interaction and sensitivity.
  • Absorption measurements using a supercontinuum light source and high-resolution spectrometer in the visible spectrum.

Main Results:

  • The functionalized PMMA fiber probe exhibited selective absorption for glucose.
  • The U-shaped geometry significantly enhanced the sensitivity of glucose detection.
  • The probe demonstrated feasibility for glucose detection in different physiological media.
  • Experimental results indicate a promising low-cost and selective glucose sensing capability.

Conclusions:

  • The developed optical fiber probe is a viable tool for selective glucose detection.
  • The combination of surface functionalization and U-shaped geometry offers enhanced sensing performance.
  • This technology holds potential for developing cost-effective and sensitive glucose monitoring devices.