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Nyquil-associated liver injury.

R T Foust1, K R Reddy, L J Jeffers

  • 1University of Miami School of Medicine, Florida.

The American Journal of Gastroenterology
|April 1, 1989
PubMed
Summary

Acetaminophen in over-the-counter drugs can cause severe liver injury, especially in chronic alcohol abusers. This study highlights two cases of liver damage linked to Nyquil, a cold remedy containing acetaminophen and alcohol.

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Area of Science:

  • Pharmacology
  • Hepatology
  • Toxicology

Background:

  • Acetaminophen is a widely used analgesic and antipyretic found in numerous over-the-counter medications.
  • Emerging evidence suggests acetaminophen's potential to induce severe hepatotoxicity.
  • Chronic alcohol consumption may heighten susceptibility to acetaminophen-induced liver injury.

Purpose of the Study:

  • To report cases of unintentional liver injury associated with a specific over-the-counter medication.
  • To investigate the role of acetaminophen and alcohol in drug-induced liver injury.

Main Methods:

  • Case report of two patients experiencing liver injury.
  • Review of medication history, focusing on acetaminophen and alcohol content.

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Main Results:

  • Two cases of unintentional liver injury were documented.
  • The injuries were associated with the ingestion of Nyquil, a liquid cold remedy.

Conclusions:

  • Nyquil, containing both acetaminophen and 25% alcohol, was implicated in causing liver injury.
  • This underscores the risk of hepatotoxicity from combined acetaminophen and alcohol exposure, even in unintentional exposures.