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Danazol-induced cholestasis.

M O Silva1, K R Reddy, T McDonald

  • 1Center for Liver Diseases, University of Miami School of Medicine, VA Medical Center, Florida.

The American Journal of Gastroenterology
|April 1, 1989
PubMed
Summary
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A rare case of Danazol-induced cholestasis in a 39-year-old female is presented. Discontinuation of Danazol led to complete resolution of jaundice and liver inflammation, highlighting drug-induced liver injury.

Area of Science:

  • Hepatology
  • Clinical Pharmacology

Background:

  • High-dose Danazol is used for various medical conditions.
  • Drug-induced liver injury (DILI) is a significant clinical concern.

Observation:

  • A 39-year-old female patient experienced jaundice and pruritus while on high-dose Danazol therapy.
  • Clinical suspicion of Danazol-induced cholestasis prompted drug discontinuation.

Findings:

  • Liver biopsy confirmed panlobular cholestasis with portal and periportal inflammation.
  • Complete resolution of cholestasis occurred within 8 weeks after discontinuing Danazol.

Implications:

  • This case underscores Danazol as a potential cause of drug-induced cholestasis.
  • Danazol-induced liver injury should be considered in the differential diagnosis of cholestatic jaundice.

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