ROS1 Rearrangement in a Case of Classic Biphasic Pulmonary Blastoma
Taylor M Jenkins1, Jennifer J D Morrissette1, John C Kucharczuk1
11 Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Abstract:
Classic biphasic pulmonary blastoma (CBPB) is a rare and aggressive type of non-small cell lung carcinoma (NSCLC) presenting in adults in the fourth to fifth decade. The prognosis is poor and after surgical resection, therapeutic options are often limited. ROS1 is a proto-oncogene receptor tyrosine kinase that has been identified in some types of NSCLC. We report a case of a 36-year-old woman with CBPB, which was subsequently found to have a ROS1 rearrangement. This is the first reported case of a ROS1-rearranged CBPB. This finding has therapeutic implications as these tumors have the potential to be treated with receptor tyrosine kinase inhibitors.
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