Related Experiment Video

Updated: Feb 16, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.2K

Runx2 overexpression compromises bone quality in acromegalic patients

Maria Teresa Valenti1, Monica Mottes2, Samuele Cheri1,3

  • 1Department of MedicineInternal Medicine, Section D, University of Verona, Verona, Italy.

Endocrine-Related Cancer
|January 4, 2018
PubMed

Insights

Acromegaly patients exhibit poor bone quality due to abnormal RUNX2 gene expression. Targeting osteoblastic lineage may improve bone health in these individuals.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Stem Cell Research

Background:

  • Acromegaly, caused by excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1), leads to high fracture risk.
  • Bone mineral density is an unreliable predictor of fractures in acromegalic patients.
  • The impact of GH/IGF-1 excess on bone microarchitecture and mesenchymal stem cells (MSCs) is not well understood.

Purpose of the Study:

  • To investigate skeletal conditions in acromegaly by analyzing bone microarchitecture.
  • To evaluate the osteogenic commitment of MSCs in acromegalic patients.
  • To determine the role of RUNX2 expression in bone impairment.

Main Methods:

  • Histomorphometric analysis of bone microarchitecture.
  • Quantification of osteogenic transcription factor RUNX2 expression in circulating MSCs.
  • Comparison of osteoblastic activity between treated and untreated patients.

Main Results:

  • Acromegalic patients display abnormal bone microarchitecture.
  • Bone impairment is linked to increased RUNX2 expression in MSCs.
  • Osteoblastic activity is reduced in patients receiving pharmacological treatment.

Conclusions:

  • Overexpression of RUNX2 is a key factor in bone impairment in acromegaly.
  • Therapeutic strategies should focus on enhancing osteoblastic lineage for bone quality improvement.
  • Inhibition of osteoclastic activity may not be the optimal approach for treating bone issues in acromegaly.
Keywords:
RUNX2acromegalymesenchymal stem cellsosteogenesis

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.6K
A Laser Capture Microdissection Protocol That Yields High Quality RNA from Fresh-frozen Mouse Bones10:11

A Laser Capture Microdissection Protocol That Yields High Quality RNA from Fresh-frozen Mouse Bones

Published on: September 16, 2019

10.1K

Related Concept Videos

Quality Control01:05

Quality Control

Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
3.1K
Quality Assurance01:19

Quality Assurance

Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
2.7K
Quality of Water01:19

Quality of Water

In concrete preparation, the quality of water is paramount as it affects the strength and durability of the concrete. Potable water is usually preferred; however, it must not have excessive sodium or potassium to prevent compromising the concrete's integrity. Water quality is typically evaluated based on impurities such as dissolved solids, chlorides, and sulfates, and its pH value is ideally between 6 and 8. Even slightly acidic natural water may be acceptable unless it contains harmful...
581
Pulse amplitude and quality01:17

Pulse amplitude and quality

Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
A weak or absent pulse may indicate reduced cardiac output or poor left ventricular contraction, which can be signs of cardiovascular dysfunction or...
3.3K
Testing Water Quality01:14

Testing Water Quality

When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
398
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
52.0K