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Fibrin and D-dimer bind to monomeric GPVI

Marie-Blanche Onselaer1, Alexander T Hardy1, Clare Wilson2

  • 1Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

Blood Advances
|January 4, 2018
PubMed
Summary

Fibrin activates platelets via glycoprotein VI (GPVI). D-dimer binding to GPVI mediates platelet spreading, but soluble D-dimer inhibits aggregation, suggesting targeted therapies.

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