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Updated: Feb 16, 2026

Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite
Published on: February 16, 2016
Nitrite-reducing ability is related to growth inhibition by nitrite in Rhodobacter sphaeroides f. sp. denitrificans
Takayuki Shimizu1,2, Kouhei Horiguchi2, Yui Hatanaka2
1a Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology , Yokohama , Japan.
Abstract:
Growth inhibition of Rhodobacter sphaeroides f. sp. denitrificans IL106 by nitrite under anaerobic-light conditions became less pronounced when the gene encoding nitrite reductase was deleted. Growth of another deletion mutant of the genes encoding nitric oxide reductase was severely suppressed by nitrite. Our results suggest that nitrite reductase increases the sensitivity to nitrite through the production of nitric oxide.
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