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Personalized physiological medicine.

Can Ince1,2

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This study introduces personalized physiological medicine for critically ill patients, focusing on dynamic physiological changes rather than genetics. It outlines four pillars to guide treatment and improve patient outcomes in intensive care settings.

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Area of Science:

  • Critical care medicine
  • Physiology
  • Personalized medicine

Background:

  • Conventional personalized medicine relies on biomarkers and gene profiling.
  • Critically ill patients require a tailored approach focusing on dynamic physiological changes.

Purpose of the Study:

  • To introduce the concept of personalized physiological medicine for critically ill patients.
  • To outline a four-pillar framework for this novel approach.

Main Methods:

  • Defining personalized physiological medicine based on time-variant pathophysiology.
  • Proposing four pillars: patient reserve, physiological monitoring, hemodynamic coherence, and adaptive modeling.

Main Results:

  • Personalized physiological medicine integrates patient frailty, organ system monitoring, resuscitation assessment, and adaptive data modeling.
  • This approach focuses on the dynamic regulation of organ systems in critical illness.

Conclusions:

  • Personalized physiological medicine offers a new paradigm for treating critically ill patients.
  • Further research and development are needed to implement this approach at the bedside.