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Updated: Feb 16, 2026

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
Published on: July 4, 2018
Seven unconfirmed ideas to improve future ICU practice
John J Marini1, Daniel De Backer2, Can Ince3,4
1University of Minnesota, Minneapolis, MN, USA. marin002@umn.edu.
This study explores unconventional clinical ideas from faculty, aiming to challenge current practices and inspire new research directions. These provocative propositions offer potential improvements for bedside patient management.
Area of Science:
- Clinical Science
- Medical Research
- Healthcare Innovation
Background:
- Clinical science often lags behind practical bedside experience due to imprecise definitions and flawed study execution.
- Experienced clinicians' intuitions, though often neglected, provide valuable perspective and can guide future research hypotheses.
- Progress in medicine relies on both empirical data from trials and insights from seasoned professionals.
Purpose of the Study:
- To present a collection of unproven, "out of the mainstream" ideas from FCCM faculty.
- To provide a defensible rationale for each unconventional proposition.
- To stimulate critical thinking and dialogue regarding potential alterations in bedside management.
Main Methods:
- Compilation of "out of the mainstream" ideas from faculty at FCCM (Fellowship of Critical Care Medicine).
- Each idea is presented with a supporting rationale.
- Propositions are designed to be provocative and stimulate discussion.
Main Results:
- A wide-ranging set of unproven ideas with clear implications for bedside management is presented.
- The faculty's unconventional propositions are detailed, each with a rationale.
- The collection aims to challenge existing paradigms and foster innovation.
Conclusions:
- Provocative, unconventional ideas can advance clinical science and bedside practices.
- Integrating faculty intuitions with empirical data can lead to novel hypotheses and research.
- Encouraging dialogue on unproven concepts is crucial for medical progress and innovation.
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