Related Experiment Video

Updated: Feb 16, 2026

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

806

Vitamin D deficiency in patients with tuberculous meningitis and its relationship with treatment outcome

G V Dangeti1, S Mailankody1, C Neeradi1

  • 1Department of Medicine.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|January 4, 2018
PubMed
Abstract

Insights

Vitamin D deficiency is common in tuberculous meningitis (TBM) patients, but serum levels do not impact treatment outcomes or interleukin-1β levels. This study highlights the prevalence of vitamin D insufficiency in TBM.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Endocrinology

Background:

  • Tuberculous meningitis (TBM) is a severe infection with limited data on vitamin D deficiency and treatment outcomes.
  • Vitamin D's potential immunomodulatory effects, possibly mediated by interleukin-1β (IL-1β), suggest a role in TBM pathogenesis.

Purpose of the Study:

  • To determine the frequency of vitamin D deficiency in TBM patients.
  • To investigate the association between vitamin D levels and TBM treatment outcomes.
  • To explore the correlation between vitamin D and IL-1β levels in cerebrospinal fluid (CSF).

Main Methods:

  • Prospective study of 40 human immunodeficiency virus-negative TBM patients in southern India.
  • Measurement of serum 25-hydroxy vitamin D (25[OH]D) and CSF IL-1β levels on pretreatment samples.
  • Definition of good outcome as survival without severe neurological disability.

Main Results:

  • Vitamin D deficiency (<20 ng/ml) was observed in 25% of patients, and insufficiency (20-30 ng/ml) in 30%.
  • Pretreatment serum 25(OH)D levels did not significantly differ between patients with good and poor outcomes (P = 0.141).
  • CSF IL-1β levels showed no significant correlation with serum 25(OH)D levels (Spearman's ρ = 0.083, P = 0.609).

Conclusions:

  • Vitamin D deficiency and insufficiency are prevalent in TBM patients.
  • Serum 25(OH)D levels are not associated with TBM treatment outcomes.
  • No correlation was found between serum vitamin D and CSF IL-1β levels in TBM patients.

More Related Videos

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer09:52

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Published on: April 26, 2018

13.2K
Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.1K

Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
4.1K
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.5K
Relationship Formation02:12

Relationship Formation

What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.3K
Ending Relationships01:28

Ending Relationships

The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...
207
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
11.0K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.8K