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A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
Published on: May 9, 2025
SIOP PODC Adapted treatment guidelines for low grade gliomas in low and middle income settings
Laila Hessissen1, Jeannette Parkes2, Nisreen Amayiri3
1Department of Hematology and Pediatric Oncology, Hospital University Ibn Sina, Rabat, Morocco.
Insights
Effective treatment for pediatric low-grade glioma (LGG) demands specialized multidisciplinary teams and facilities. This article offers management guidelines for pediatric LGG tailored to varying resource levels in low and middle-income countries.
Area of Science:
- Pediatric Oncology
- Neuro-oncology
- Global Health
Background:
- Pediatric low-grade glioma (LGG) treatment necessitates comprehensive multidisciplinary teams and advanced facilities.
- Resource limitations in low and middle-income countries (LMIC) hinder effective LGG management and follow-up.
- Existing treatment protocols may not be universally applicable due to varying healthcare infrastructure.
Purpose of the Study:
- To provide practical, tiered management recommendations for pediatric low-grade glioma.
- To adapt LGG treatment strategies based on available resources in different healthcare settings.
- To improve outcomes for children with LGG in LMIC by outlining feasible approaches.
Main Methods:
- Review of current pediatric LGG management guidelines.
- Analysis of resource requirements for neurosurgery, neuroradiology, pathology, radiotherapy, and chemotherapy.
- Development of a tiered framework for LGG treatment based on facility availability.
Main Results:
- Identification of essential components for effective pediatric LGG care.
- Categorization of management strategies according to resource levels (basic, intermediate, advanced).
- Specific recommendations for diagnosis, treatment, and complication management at each resource level.
Conclusions:
- Accessible pediatric LGG management is achievable through tailored, resource-appropriate strategies.
- Implementing tiered recommendations can enhance care quality and accessibility in LMIC.
- Multidisciplinary collaboration and adaptation are key to improving outcomes for children with LGG globally.
Abstract:
Effective treatment of children with low grade glioma (LGG) requires a functioning multi-disciplinary team with adequate neurosurgical, neuroradiological, pathological, radiotherapy and chemotherapy facilities and personnel. In addition, the treating centre should have the capacity to manage a variety of LGG and treatment-associated complications. These requirements have made it difficult for many centers in low and middle-income countries (LMIC) to offer effective treatment and follow up. This article provides management recommendations for children with LGG according to the level of facilities available.
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