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Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Group Therapy01:26

Group Therapy

472
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
472
Gene Flow02:39

Gene Flow

38.1K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
38.1K
Gene Families01:57

Gene Families

10.0K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
10.0K
Gene Conversion02:08

Gene Conversion

10.7K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.7K
What is Gene Expression?01:42

What is Gene Expression?

197.2K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
197.2K

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Related Experiment Video

Updated: Feb 16, 2026

Production and Purification of Baculovirus for Gene Therapy Application
06:11

Production and Purification of Baculovirus for Gene Therapy Application

Published on: April 9, 2018

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[Gene therapy – from idea to reality].

Edvard Smith1, Pontus Blomberg2

  • 1Karolinska institutet Department of Laboratory Medicine - Stockholm, Sweden Karolinska institutet Department of Laboratory Medicine - Stockholm, Sweden.

Lakartidningen
|January 4, 2018
PubMed
Summary

Gene therapy has evolved from concept to clinical reality over 45 years, with significant advances in viral vectors, cell therapies, and gene editing. Challenges remain in scaling up manufacturing and ensuring cost-effective patient access.

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genetics

Background:

  • Gene therapy, proposed 45 years ago, has recently shown significant clinical benefits.
  • Early gene therapy approaches focused on viral vectors to deliver therapeutic genes.

Observation:

  • Successful treatments include primary immunodeficiencies and hemophilias.
  • Cellular therapies involve genetically modified cells, like CAR T-cells for leukemia.
  • Oligonucleotides and gene editing represent newer, impactful therapeutic modalities.

Findings:

  • Significant clinical benefits are now being demonstrated in gene therapy.
  • Engineered viruses, modified cells, and oligonucleotides are key delivery methods.
  • Gene editing has transitioned from theoretical to practical clinical application.

Implications:

  • Gene therapy offers new hope for previously intractable genetic disorders.
  • Manufacturing scale-up and cost-effectiveness are critical future challenges.
  • The field is rapidly advancing, promising broader therapeutic applications.