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Elevated High-Sensitivity Troponin I During Living Donor Liver Transplantation Is Associated With Postoperative

Jungchan Park1, Seung Hwa Lee2, Sangbin Han1

  • 1Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Transplantation
|January 4, 2018
PubMed

Insights

Elevated cardiac troponin levels after liver transplant indicate myocardial injury, increasing hospital death or graft failure risk. Female sex, ischemia time, and postreperfusion syndrome predict this injury.

Area of Science:

  • Cardiology
  • Hepatology
  • Transplantation Surgery

Background:

  • Myocardial injury after living donor liver transplantation (LDLT) is a concern.
  • High-sensitivity cardiac troponin I (hs-cTnI) is a key biomarker for detecting cardiac issues.
  • Understanding risk factors and outcomes of myocardial injury post-LDLT is crucial.

Purpose of the Study:

  • To evaluate risk factors for myocardial injury after LDLT.
  • To assess the clinical outcomes associated with myocardial injury detected by hs-cTnI post-LDLT.

Main Methods:

  • Adult LDLT recipients (n=313) with normal preoperative hs-cTnI were studied (Jan 2011-Dec 2016).
  • Myocardial injury defined as hs-cTnI > 0.04 ng/mL post-LDLT.
  • Outcomes compared between recipients with and without myocardial injury.

Main Results:

  • 50.8% of recipients showed elevated hs-cTnI post-LDLT.
  • Myocardial injury was linked to significantly higher in-hospital death or graft failure (7.6% vs 1.9%).
  • Independent predictors included female sex, ischemia time, and postreperfusion syndrome.

Conclusions:

  • Post-LDLT myocardial injury, indicated by elevated hs-cTnI, is associated with adverse in-hospital outcomes.
  • Early detection and management of myocardial injury are vital in LDLT recipients.
Abstract

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