Related Experiment Video

Updated: Feb 16, 2026

Whole-body PET/MRI of Pediatric Patients: The Details That Matter
10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

15.4K

Clinical Characteristics of Pediatric Patients With Carbon Monoxide Poisoning

Kinjal N Sethuraman, Taylor M Douglas1, Barbara B Bostick2,3

  • 1University of Maryland School of Medicine.

Pediatric Emergency Care
|January 4, 2018
PubMed

Insights

This study analyzed children treated for carbon monoxide (CO) poisoning with hyperbaric oxygen therapy. Findings indicate age and lactate levels correlate with CO poisoning severity, not necessarily presenting symptoms.

Area of Science:

  • Pediatrics
  • Toxicology
  • Emergency Medicine

Background:

  • Carbon monoxide (CO) poisoning is a significant public health concern, frequently managed with hyperbaric oxygen therapy.
  • Limited data exists on the specific clinical profiles of pediatric patients undergoing this treatment for CO poisoning.

Purpose of the Study:

  • To delineate the clinical characteristics of children treated with hyperbaric oxygen therapy for CO poisoning.
  • To describe patient demographics, carboxyhemoglobin levels, and presenting symptoms in this cohort.

Main Methods:

  • Retrospective review of medical records for children (<19 years) treated between 2008-2013.
  • Analysis of demographic data, serum carboxyhemoglobin (COHb) levels, and presenting symptoms.
  • Inferential statistical analyses to identify correlations.

Main Results:

  • Forty-seven children were included; mean age was 8.9 years, mean COHb was 14.3%.
  • No significant correlation between symptom severity and COHb levels was observed.
  • Neurologic symptoms were more frequent with COHb levels >25%; increasing age and lactate levels correlated with higher COHb.

Conclusions:

  • Serum COHb levels did not consistently correlate with presenting symptoms in pediatric CO poisoning.
  • Age and lactate levels showed a correlation with COHb levels in this pediatric population.
  • Further research may elucidate the complex interplay of factors in pediatric CO poisoning management.
Abstract

More Related Videos

Guidelines for Elective Pediatric Fiberoptic Intubation11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.7K
Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults08:56

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults

Published on: November 7, 2014

14.4K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
281
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
334
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
256
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
318
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.3K
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
934