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One consensual depression diagnosis tool to serve many countries: a challenge! A RAND/UCLA methodology.

P Nabbe1, J Y Le Reste2, M Guillou-Landreat3

  • 1EA 7479 SPURBO, Department of General Practice, Université de Bretagne Occidentale, Brest, France. patrice.nabbe@univ-brest.fr.

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|January 5, 2018
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Summary

General Practitioner (GP) researchers need a validated depression diagnostic tool for European multi-center studies. The Hopkins Symptoms Checklist-25 (HSCL-25) was selected for its effectiveness, reliability, and ergonomics.

Keywords:
Delphi procedureDepression diagnosis toolMulticultural consensusRAND/UCLA appropriateness method

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Area of Science:

  • Psychiatry
  • General Practice Research
  • Clinical Psychology

Background:

  • European General Practitioner (GP) researchers require a validated diagnostic tool for depression to facilitate multi-center collaborative research in daily practice.
  • Existing tools lacked consensual validation for widespread European clinical research use.

Purpose of the Study:

  • To identify and select the optimal depression diagnostic tool for European GP clinical research.
  • The chosen tool needed to be validated against psychiatric examination (DSM criteria), effective, reliable, and ergonomic.

Main Methods:

  • A systematic literature review (SLR) identified 7 potential depression diagnostic tools.
  • A RAND/UCLA consensus method, combining Delphi and nominal group techniques, was employed with European GP researchers.
  • Effectiveness was assessed using the Youden index, reliability by Cronbach's alpha, and ergonomics were evaluated through face-to-face testing.

Main Results:

  • Two instruments, the Hospital Anxiety and Depression Scale and the Hopkins Symptoms Checklist-25 (HSCL-25), met initial effectiveness and reliability criteria.
  • Following face-to-face ergonomic testing, the HSCL-25 was selected as the preferred tool.
  • A multicultural consensus was achieved, endorsing the HSCL-25 for European collaborative depression research.

Conclusions:

  • The HSCL-25 is recommended as a validated, effective, reliable, and ergonomic diagnostic tool for depression in European GP research.
  • This consensus facilitates the selection of homogeneous populations for multi-center European research, enhancing study validity.