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Variables of patient-controlled analgesia. 1. Bolus size
H Owen1, J L Plummer, I Armstrong
1Department of Anaesthesia and Intensive Care Flinders University of South Australia, Bedford Park.
Anaesthesia
|January 1, 1989
Abstract:
The efficacy of a range of demand doses of morphine for patient-controlled analgesia was studied. Patients who self-administered the smallest dose (0.5 mg) were frequently unable to achieve good pain control; patients who received the largest dose (2 mg) had a high incidence of ventilatory depression. A dose of 1 mg was the best increment under the conditions of this study but the relationship between increment and lockout interval requires consideration.