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F-box proteins in epigenetic regulation of cancer

Jia Shen1, Charles Spruck1

  • 1Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, San Diego, California, USA.

Oncotarget
|January 5, 2018
PubMed

Insights

Epigenetic abnormalities, including DNA methylation and histone modifications, are key drivers of cancer. F-box proteins play a crucial role in regulating these epigenetic processes and their dysregulation contributes to cancer development.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic abnormalities are critical in cancer initiation and progression, comparable to genetic alterations.
  • The epigenetic network, involving histone modifications and DNA methylation, is extensively altered in human cancers.
  • F-box proteins are key components of SCF E3 ubiquitin ligases, influencing epigenetic regulation.

Purpose of the Study:

  • To review the role of F-box proteins in cellular epigenetic regulation.
  • To discuss how dysregulation of F-box proteins contributes to cancer development.

Main Methods:

  • Literature review of F-box proteins in cancer epigenetics.
  • Analysis of the impact of F-box protein dysregulation on epigenetic balance.

Main Results:

  • F-box proteins directly and indirectly modulate epigenetic regulatory mechanisms.
  • Dysregulated F-box protein function is linked to various human cancers.

Conclusions:

  • F-box proteins are integral to maintaining epigenetic homeostasis.
  • Targeting F-box proteins may offer novel therapeutic strategies for cancer treatment.
Keywords:
E3 ubiquitin ligaseF-box proteinSCFcancerepigenetics

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