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Updated: Feb 16, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
Non-Clinical Models for Neurodegenerative Diseases: Therapeutic Approach and Drug Validation in Animal Models
Caridad Ivette Fernandez1, Jessica López2, Lázara Martinez3
1Basic Division, International Center of Neurological Restoration (CIREN), Havana 11300, Cuba.
Abstract:
In 2016, 19.8% of the Cuban population was aged 60 or over. As a result, age-associated degenerative diseases and other diseases have become priority targets from a prophylactic, diagnostic and therapeutic perspective. As a result, the Cuban biomedical scientific community has addressed its basic, preclinical and epidemiological research in order to rise up to the challenge. A firm step in this direction has been the international congress "State of the art in non-clinical models for neurodegenerative diseases" which has brought together preclinical and clinical researchers, technicians and regulatory staff members from different countries to review the state of the art in neurodegenerations, find unifying ideas, objectives and collaborations or partnership. The objective is to expose the perspectives of new biotechnological products from Cuba and other countries from the diagnostic, therapeutic and neuroprotective point of view. It is crucial, therefore, that the irreplaceable role of laboratory animals in achieving these objectives is understood but they must be used in rational, adequate and ethical manner. We expose the current development trends in this field, being of common interest to the work directed to the search for potential drugs, diagnostic tools and the promotion of changes in lifestyle as a preventive projection.
Insights
Cuba
Area of Science:
- Biomedical Sciences
- Neuroscience
- Gerontology
Background:
- Cuba's aging population (19.8% over 60 in 2016) necessitates focus on age-associated diseases.
- Neurodegenerative diseases are a growing public health concern, requiring advanced research.
- The Cuban biomedical community is actively pursuing research to address these challenges.
Purpose of the Study:
- To review the state-of-the-art in non-clinical models for neurodegenerative diseases.
- To foster collaboration and identify unifying objectives among international researchers.
- To explore new biotechnological products for diagnosis, therapy, and neuroprotection.
Main Methods:
- International congress on non-clinical models for neurodegenerative diseases.
- Review of current research trends in neurodegeneration.
- Discussion on the ethical and rational use of laboratory animals in research.
Main Results:
- Identified key areas for advancement in neurodegenerative disease research.
- Highlighted the importance of international collaboration and knowledge exchange.
- Emphasized the role of non-clinical models in developing diagnostic and therapeutic strategies.
Conclusions:
- Continued research and international collaboration are vital for combating neurodegenerative diseases.
- Development of novel biotechnological products is crucial for improved patient outcomes.
- Ethical and rational use of animal models remains essential for scientific progress in this field.
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