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Pacritinib to inhibit JAK/STAT signaling in refractory metastatic colon and rectal cancer

Thomas Regenbogen1, Ling Chen, Kathryn Trinkaus

  • 1Division of Oncology, Washington University, St. Louis, MO, USA.

Journal of Gastrointestinal Oncology
|January 5, 2018
PubMed
Abstract

Insights

Pacritinib, a JAK/STAT inhibitor, showed no objective responses in refractory colorectal cancer patients. The trial was halted due to limited benefit and an FDA hold, indicating poor efficacy for this patient group.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Limited treatment options exist for refractory colorectal cancer.
  • The JAK/STAT pathway is implicated in cancer inflammation.
  • Pacritinib targets the JAK/STAT pathway.

Purpose of the Study:

  • To evaluate pacritinib's efficacy in metastatic refractory colorectal adenocarcinoma.
  • To assess the inhibition of the JAK/STAT pathway as a therapeutic strategy.

Main Methods:

  • Single-arm institutional trial.
  • Administered pacritinib 400 mg daily orally.
  • Enrolled patients refractory to at least two prior treatments.

Main Results:

  • Trial discontinued early due to FDA hold and lack of benefit.
  • Seven patients evaluated; one had stable disease, six progressed.
  • No objective responses observed; adverse events were grade 2 or lower.

Conclusions:

  • Pacritinib demonstrated no objective responses in evaluable patients.
  • Trial halted due to low likelihood of meeting progression-free survival goals.
  • Further investigation of pacritinib in this setting is not supported.
Keywords:
Pacritinibcolorectal cancerrefractory

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