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Combining Behavior and EEG to Study the Effects of Mindfulness Meditation on Episodic Memory

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Individual differences in EEG correlates of recognition memory due to DAT polymorphisms.

Paolo Medrano¹, Erika Nyhus², Andrew Smolen³

¹Psychology Department University of New Hampshire Durham NH USA.

Brain and Behavior

|January 5, 2018

Summary

Genetic variations in dopamine transporter expression impact recognition memory. Individuals with higher dopamine transporter expression show slower reaction times and altered brain activity, suggesting a significant role in memory processes.

Keywords:

DAT item memory old/new effect oscillations

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Area of Science:

Neuroscience
Cognitive Neuroscience
Genetics

Background:

Dopaminergic genes are implicated in recognition memory.
The specific influence of dopamine transporter (DAT) expression on memory's behavioral and EEG correlates remains unclear.

Purpose of the Study:

To investigate how genetic variations in the DAT gene affect dopaminergic functioning.
To determine the impact of DAT gene variations on the behavioral and electroencephalography (EEG) markers of recognition memory.

Main Methods:

Fifty-eight participants completed an item recognition task with EEG monitoring.
Event-related potentials (ERPs) and spectral perturbations were analyzed in relation to DAT genotype (10/10 homozygotes vs. 9R-carriers).

Main Results:

10/10 homozygotes exhibited slower reaction times for both hits and correct rejections compared to 9R-carriers.
10/10 homozygotes lacked the typical left parietal old/new effect in ERPs.
Greater decreases in alpha and beta oscillatory activity were observed in 10/10 homozygotes during memory retrieval.

Conclusions:

Dopamine transporter gene polymorphisms significantly influence recognition memory performance.
Altered ERPs and oscillatory activity in 10/10 homozygotes suggest impaired memory retrieval mechanisms.
These findings highlight the critical role of DAT expression in cognitive functions related to memory.