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Updated: Feb 16, 2026

Endoscopic Cholesteatoma Surgery
Published on: January 19, 2022
Outpatient management of cholesteatoma with canal wall reconstruction tympanomastoidectomy
Richard Kao1, Todd Wannemuehler1, Charles W Yates1
1Department of Otolaryngology-Head and Neck Surgery Indiana University School of Medicine Indianapolis Indiana U.S.A.
Objectives:
The postoperative wound infection rate for canal wall reconstruction (CWR) tympanomastoidectomy with mastoid obliteration in the treatment of chronic otitis media with cholesteatoma has been reported to be 3.6%. Postoperative administration of 24-48 hours of intravenous antibiotics has been recommended. We aim to determine the infection rate of CWR with postoperative outpatient oral antibiotics.
Study Design:
Institutional review board-approved retrospective case review.
Setting:
Tertiary referral center. Patients: Retrospective review of consecutive patients who underwent CWR tympanomastoidectomy with mastoid obliteration at a single institution from 2014 to 2016. Main Outcome Measure: Patient characteristics (age, sex) were calculated. Rate of postoperative complications and infections within 1 month of surgery were calculated. Comparison to previous published infection rates with postoperative intravenous antibiotics.
Results:
51 patients underwent CWR followed by outpatient oral antibiotics with a mean age of 25.9 years (16 patients were less than 10 years old). There were no postoperative wound infections. Outpatient antibiotics showed non-inferiority to IV antibiotic historic controls (0% vs. 3.6%; 95% confidence interval [CI], 0-6.09%; p = 0.03). One patient had small postoperative wound dehiscence with CSF leak that was managed conservatively. One patient developed Clostridium difficile colitis on postoperative day 2.
Conclusions:
The infection rate after CWR tympanomastoidectomy with use of outpatient antibiotics is low and is non-inferior to a historic cohort treated with inpatient intravenous antibiotics. A larger randomized controlled trial is warranted.
Level Of Evidence:
4.
Insights
Postoperative oral antibiotics after canal wall reconstruction tympanomastoidectomy show a low infection rate, matching historic intravenous antibiotic effectiveness for chronic otitis media with cholesteatoma treatment.
Area of Science:
- Otolaryngology
- Infectious Disease
- Surgical Outcomes
Background:
- Chronic otitis media with cholesteatoma requires surgical intervention, often canal wall reconstruction (CWR) tympanomastoidectomy with mastoid obliteration.
- Postoperative wound infections following CWR are a concern, with a reported rate of 3.6%.
- Intravenous antibiotics for 24-48 hours post-surgery have been the standard recommendation.
Purpose of the Study:
- To evaluate the postoperative wound infection rate using outpatient oral antibiotics after CWR tympanomastoidectomy.
- To compare the efficacy of outpatient oral antibiotics with historical data of inpatient intravenous antibiotics.
Main Methods:
- Retrospective case review of 51 patients undergoing CWR tympanomastoidectomy with mastoid obliteration.
- Patients received postoperative outpatient oral antibiotics.
- Infection rates and complications within one month of surgery were analyzed.
Main Results:
- No postoperative wound infections were observed in the study group (0%).
- Outpatient oral antibiotics demonstrated non-inferiority to historical intravenous antibiotic use (0% vs. 3.6%).
- One case of wound dehiscence with CSF leak and one case of C. difficile colitis occurred.
Conclusions:
- Canal wall reconstruction tympanomastoidectomy with mastoid obliteration using postoperative outpatient oral antibiotics results in a low infection rate.
- This approach is non-inferior to historical treatment with inpatient intravenous antibiotics.
- Further investigation via a randomized controlled trial is recommended.
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