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Effect on airway resistance of ketamine by aerosol in guinea pigs
M J Rock1, S Reyes de la Rocha, M Lerner
1Department of Pediatrics, University of Oklahoma Medical Center, Oklahoma City.
Anesthesia and Analgesia
|April 1, 1989
Abstract:
The effect of aerosolized ketamine hydrochloride was investigated by measuring airway resistance with a two-compartment plethysmograph in guinea pigs challenged with histamine. In the first phase of the study, treatment with ketamine prior to histamine challenge did not protect against elevation of airway resistance. In the second phase of the study, ketamine inhalation after histamine challenge did not significantly diminish airway resistance. Aerosolized ketamine is not recommended for use in human subjects with asthma.