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Related Concept Videos

Quality Control01:05

Quality Control

3.1K
Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
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Quality Assurance01:19

Quality Assurance

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Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
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Quality of Water01:19

Quality of Water

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In concrete preparation, the quality of water is paramount as it affects the strength and durability of the concrete. Potable water is usually preferred; however, it must not have excessive sodium or potassium to prevent compromising the concrete's integrity. Water quality is typically evaluated based on impurities such as dissolved solids, chlorides, and sulfates, and its pH value is ideally between 6 and 8. Even slightly acidic natural water may be acceptable unless it contains harmful...
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Rate-Determining Steps03:08

Rate-Determining Steps

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Relating Reaction Mechanisms
In a multistep reaction mechanism, one of the elementary steps progresses significantly slower than the others. This slowest step is called the rate-limiting step (or rate-determining step). A reaction cannot proceed faster than its slowest step, and hence, the rate-determining step limits the overall reaction rate.
The concept of rate-determining step can be understood from the analogy of a 4-lane freeway with a short-stretch of traffic-bottleneck caused due to...
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Pulse amplitude and quality01:17

Pulse amplitude and quality

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Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
A weak or absent pulse may indicate reduced cardiac output or poor left ventricular contraction, which can be signs of cardiovascular dysfunction or...
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Testing Water Quality01:14

Testing Water Quality

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When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
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Related Experiment Video

Updated: Feb 16, 2026

Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol
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How to do high-quality clinical research 1: First steps.

Peter Sandercock1, William Whiteley1

  • 1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

International Journal of Stroke : Official Journal of the International Stroke Society
|January 5, 2018
PubMed
Summary

This series introduces essential skills for high-quality clinical research. It guides clinicians on research methodology training, question refinement, and ensuring correct methods and data analysis for practice-relevant projects.

Keywords:
Researchepidemiologymentoringproject managementstatisticstraining

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Area of Science:

  • Clinical Research Methodology
  • Medical Education

Background:

  • Effective clinical research is crucial for evidence-based practice.
  • Many clinicians require guidance to initiate and conduct research projects.
  • Resource-limited settings present unique challenges for clinical research.

Purpose of the Study:

  • To outline foundational skills for conducting quality clinical research.
  • To support researchers at all career stages, especially those new to the field.
  • To provide resources for experienced researchers and clinicians in resource-poor settings.

Main Methods:

  • Focus on acquiring appropriate research methodology training.
  • Emphasis on selecting and refining clinically relevant research questions.
  • Guidance on aligning research methods and data analysis plans with the research question.

Main Results:

  • This paper establishes the framework for a five-part series on clinical research.
  • It identifies key skills for clinicians to lead practice-relevant research.
  • It highlights the importance of methodological rigor from question formulation to data analysis.

Conclusions:

  • Developing essential research skills is vital for clinicians.
  • This series aims to promote reliable clinical research and inform practice.
  • Proper training and planning are fundamental for successful clinical research endeavors.