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Related Experiment Video

Updated: Feb 16, 2026

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

Monodisperse Microshell Structured Gelatin Microparticles for Temporary Chemoembolization.

Bohyun Kim, Sang Woo Han, Song-Ee Choi

¹Eindhoven University of Technology, WTB/MaTe and ICMS , Eindhoven, The Netherlands.

Biomacromolecules

|January 5, 2018

Summary

Researchers developed a microfluidic method to create uniform gelatin microparticles (GMPs) with a microshell structure. These GMPs offer controlled degradation and drug release for minimally invasive embolization procedures.

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Area of Science:

Biomaterials Science
Minimally Invasive Medical Procedures

Background:

Embolization is a minimally invasive procedure to block blood vessels.
Current embolic particles face challenges with size variation and unpredictable degradation.
There is a need for precisely controlled embolic agents.

Purpose of the Study:

To develop a microfluidic method for fabricating highly monodisperse gelatin microparticles (GMPs).
To engineer GMPs with a unique microshell structure for controlled degradation.
To evaluate the performance of these GMPs in a simulated embolic environment.

Main Methods:

Utilized microfluidics to create uniform gelatin emulsion precursors.
Employed glutaraldehyde cross-linking via inbound diffusion for microshell formation.
Conducted micromechanic studies in an artificial blood vessel model.

Main Results:

Successfully fabricated highly monodisperse gelatin microparticles (GMPs) with a defined microshell structure.
Demonstrated extraordinary and controllable degradation kinetics of the GMPs.
Showcased controlled rupturing and drug release capabilities of the GMPs.

Conclusions:

The microfluidic approach enables precise fabrication of advanced embolic agents.
The microshell structure of GMPs allows for tunable degradation and targeted drug delivery.
These novel GMPs hold significant potential for improving embolization therapies.