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Updated: Feb 16, 2026
08:42
A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
8.2K
Mesenteric Oxygenation Changes Associated With Necrotizing Enterocolitis and Pneumoperitoneum After Multiple Blood
1Department of Physiological and Technological Nursing, College of Nursing, Augusta University, Georgia (Dr Marin); and University of Connecticut Health Science Center, Farmington, and Connecticut Children's Medical Center, Hartford, Connecticut (Dr Moore).
Summary
Near-infrared spectroscopy (NIRS) detected mesenteric ischemia in a premature infant after packed red blood cell (PRBC) transfusions, potentially aiding early necrotizing enterocolitis (NEC) detection when other monitoring failed.
Area of Science:
- Neonatal physiology
- Critical care medicine
- Medical technology innovation
Background:
- Necrotizing enterocolitis (NEC) in premature infants presents multifactorial challenges for prediction.
- Packed red blood cell (PRBC) transfusions are controversially linked to NEC development in anemic preterm infants.
Observation:
- This case study details an extremely low birth-weight infant who developed NEC with pneumoperitoneum post-PRBC transfusion.
- Continuous near-infrared spectroscopy (NIRS) monitored mesenteric tissue oxygenation trends.
Findings:
- The infant exhibited severe, prolonged mesenteric oxygenation reductions after PRBC transfusions.
- Standard physiologic monitoring did not signal intestinal hypoperfusion or impending NEC.
Implications:
- NIRS can identify early tissue ischemia during NEC development, potentially guiding interventions.
- Further research is needed to validate NIRS as a routine clinical tool for preterm infants.
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