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The effect of caffeine on exercise tolerance and left ventricular function in patients with coronary artery disease
A T Hirsch1, E V Gervino, S Nakao
1Charles A. Dana Research Institute, Boston, Massachusetts.
Insights
Caffeine consumption, equivalent to three cups of coffee, did not negatively impact exercise performance or heart function in patients with coronary artery disease. These findings suggest caffeine is safe for individuals with exercise-induced ischemia on antianginal therapy.
Area of Science:
- Cardiology
- Pharmacology
- Exercise Physiology
Background:
- Coronary artery disease (CAD) patients often experience exercise-induced ischemia.
- Caffeine's stimulant effects raise concerns about its impact on cardiovascular function and exercise capacity.
Purpose of the Study:
- To evaluate the effects of acute oral caffeine intake on treadmill exercise performance.
- To assess caffeine's impact on systolic and diastolic left ventricular function in CAD patients.
Main Methods:
- A randomized, double-blind, placebo-controlled trial was conducted.
- Participants with stable CAD underwent maximal exercise treadmill testing and echocardiography.
- Tests were performed at baseline and after ingesting either a placebo or 250 mg of caffeine.
Main Results:
- Caffeine ingestion did not alter resting heart rate, blood pressure, or left ventricular function.
- Exercise duration, time to angina, and ST depression were not significantly different between caffeine and placebo groups.
- Peak systolic blood pressure during exercise showed a small increase with caffeine, but clinical outcomes remained unchanged.
Conclusions:
- Caffeine, in amounts equivalent to three cups of coffee, appears safe for patients with exercise-induced ischemia.
- Appropriate antianginal therapy allows tolerance of caffeine without detrimental effects on ischemia intensity, cardiac function, or exercise duration.
Study Objective:
To determine whether acute oral caffeine ingestion by patients with coronary artery disease results in decreased treadmill exercise performance or deterioration of echocardiographic measures of systolic or diastolic left ventricular function.
Design:
Randomized, double-blind, placebo-controlled trial.
Setting:
Referral-based cardiovascular exercise laboratory at an urban teaching hospital.
Patients:
Thirteen volunteers with clinically stable coronary artery disease who had exercise tests after a 2-week caffeine-free washout period. Patients continued treatment with standard antianginal medications during the study period.
Interventions:
Maximal exercise treadmill testing and exercise echocardiography were done at baseline, after acute ingestion of a placebo beverage (97% caffeine-free coffee), or after drinking an identical beverage containing 250 mg of caffeine sodium benzoate.
Measurements And Main Results:
Acute ingestion of caffeine produced a serum level of 4.50 +/- 0.16 micrograms/mL, but had no effect on resting supine heart rate, blood pressure, left ventricular fractional shortening, posterior left ventricular wall thinning or peak rates of increase in left ventricular diastolic dimension. Despite a small increase in peak systolic blood pressure during exercise (baseline, 153 +/- 8; placebo, 154 +/- 8; caffeine, 161 +/- 7 mm Hg; P less than 0.05), exercise duration, time to onset of angina, and time to 0.1 mV ST depression did not differ after ingestion of placebo or caffeine. Rate-pressure product at onset of angina and onset of 0.1 mV of ST depression were also unchanged. In response to exercise, echocardiographic measures of left ventricular systolic and diastolic function were unchanged after caffeine compared with placebo ingestion.
Conclusions:
These data suggest that patients with exercise-induced ischemia who are receiving appropriate antianginal therapy tolerate the caffeine-equivalent of three cups of coffee without detrimental effect on intensity of ischemia, myocardial function, or exercise duration.
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