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Factors Associated with Time to Full Feeds in Preterm Very Low Birth Weight Infants

Gaurav Patwardhan1, Ankit Soni1, Nitin Rachwani1

  • 1King Edward Memorial Hospital and Research Centre, Pune, Maharashtra 411011, India.

Journal of Tropical Pediatrics
|January 5, 2018
PubMed

Insights

Gestational age, sepsis, and patent ductus arteriosus (PDA) significantly impact time to full feeds (TFF) in preterm infants. Lower gestation and conditions like sepsis and PDA prolong TFF, affecting infant nutrition and growth.

Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Clinical Nutrition

Background:

  • Feeding intolerance is a common challenge in preterm infants, delaying nutritional support.
  • Standardized feeding regimens (SFR) and probiotic supplementation (RPS) are often used to manage preterm infant feeding.

Purpose of the Study:

  • To investigate factors influencing the time to full feeds (TFF) in preterm infants receiving SFR and RPS.
  • To identify key clinical predictors of TFF in this vulnerable population.

Main Methods:

  • Prospective cohort study involving preterm infants weighing ≤1500g.
  • Statistical analyses included Pearson's correlation, Mann-Whitney test, and multivariate analysis.
  • Data collected on gestational age, birth weight, Apgar scores, and specific medical conditions.

Main Results:

  • Median TFF was 11 days for 304 preterm infants; 37 died before reaching full feeds.
  • Lower gestational age and birth weight were inversely correlated with TFF.
  • Sepsis, patent ductus arteriosus (PDA), and respiratory distress syndrome were directly correlated with TFF.
  • Multivariate analysis identified gestational age, sepsis, and PDA as significant predictors of TFF.

Conclusions:

  • In preterm infants on SFR and RPS, shorter gestational age is associated with shorter TFF.
  • Sepsis and PDA significantly prolong TFF in preterm infants.
  • These findings highlight critical factors influencing nutritional outcomes in preterm infants.
Abstract

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